What action should a nurse take immediately during a generalized tonic-clonic seizure?

Turning the patient onto their side is the most appropriate and immediate action during a generalized tonic-clonic seizure. This position helps to maintain an open airway and reduces the risk of aspiration, which is crucial since patients may become unable to protect their airways during a seizure. Placing the patient in a lateral position allows any secretions or vomit to drain out of the mouth rather than into the airway, thus preventing breathing complications.

In addition, while it is important to ensure the patient's safety and to prevent injury during the seizure, other actions like restraining the patient can lead to injury or exacerbate the seizure by creating unnecessary stress. Placing a tongue depressor in the mouth is a safety hazard that can lead to broken teeth or obstruct the airway. Although calling for help may be necessary depending on the situation, the immediate focus during the seizure should be on protecting the patient and maintaining airway patency.